COVID-19 for the Cardiologist: A Current Review of the Virology, Clinical Epidemiology, Cardiac and Other Clinical Manifestations and Potential Therapeutic Strategies.
Identifieur interne : 000931 ( Main/Exploration ); précédent : 000930; suivant : 000932COVID-19 for the Cardiologist: A Current Review of the Virology, Clinical Epidemiology, Cardiac and Other Clinical Manifestations and Potential Therapeutic Strategies.
Auteurs : Deepak Atri [États-Unis] ; Hasan K. Siddiqi [États-Unis] ; Joshua Lang [États-Unis] ; Victor Nauffal [États-Unis] ; David A. Morrow [États-Unis] ; Erin A. Bohula [États-Unis]Source :
- JACC. Basic to translational science [ 2452-302X ] ; 2020.
Abstract
The coronavirus disease-2019 (COVID-19), a contagious disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV2), has reached pandemic status. As it spreads across the world, it has overwhelmed healthcare systems, strangled the global economy and led to a devastating loss of life. Widespread efforts from regulators, clinicians and scientists are driving a rapid expansion of knowledge of the SARS-CoV2 virus and the COVID-19 disease. We review the most current data with a focus on our basic understanding of the mechanism(s) of disease and translation to the clinical syndrome and potential therapeutics. We discuss the basic virology, epidemiology, clinical manifestation, multi-organ consequences, and outcomes. With a focus on cardiovascular complications, we propose several mechanisms of injury. The virology and potential mechanism of injury form the basis for a discussion of potential disease-modifying therapies.
DOI: 10.1016/j.jacbts.2020.04.002
PubMed: 32292848
Affiliations:
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